john hawks weblog

paleoanthropology, genetics and evolution

Sickle cell chimeras

Thu, 2009-12-10 07:30 -- John Hawks

Many of us use sickle cell as an example in classes. I always do so while noting the progress that has been made in treating the condition in Westernized contexts -- otherwise students walk away with a very misleading view of today's medical situation for patients expressing the sickle trait.

The news today is full of a new advance in treatment -- it's stem cell transplants in bone marrow, and the new aspect is a better protocol for adult sufferers (children have benefited from these transplants for some time).

I'll link to the research paper's abstract instead of a news story:

Conclusions: A protocol for nonmyeloablative allogeneic hematopoietic stem-cell transplantation that includes total-body irradiation and treatment with alemtuzumab and sirolimus can achieve stable, mixed donor–recipient chimerism and reverse the sickle cell phenotype.

You've got to like a treatment where the desired outcome is "chimerism."

Neandertals

For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.

Denisova

From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.

Acceleration

The advent of agriculture caused natural selection to speed up greatly in humans. We're uncovering some of the ways that populations have rapidly changed during the last 10,000 years.

Malapa

Just outside Johannesburg, the Malapa site is producing some of the most exciting finds in human evolution. This site is the headquarters of the Malapa Soft Tissue Project.