john hawks weblog

paleoanthropology, genetics and evolution

peer review

  • Is Nature Genetics something more than the GWAS Catalog?

    Tue, 2012-01-03 23:03 -- John Hawks

    I always look through the table of contents of Nature Genetics, which I have delivered to my inbox. Over the last couple of years, the journal has included a high fraction of papers that are either original genome-wide association studies or meta-analyses of multiple studies. These are substantial studies that have dozens of authors, on conditions of broad interest -- for example, this month there is a meta-analysis paper about type 2 diabetes. So I have no criticism of the journal, these studies need to be published somewhere.

    But others might be impatient with this course of research. The studies are formulaic: put together a large set of cases and controls, run them across a genotyping chip, and report the results. In the current issue, the journal's editorial board enters an op/ed suggesting that the current situation will not continue forever, because GWAS studies just aren't that interesting anymore [1]:

    Which Mendelian variants produce results suitable for publication in the journal? Our general principles are and have always been to select papers for review by the amount of new data and new ideas and the resource value contained within. Papers must meet current field-specific standards set by our latest benchmark papers and referee advice. Finally, we consider the value of the paper as a research tool, prioritizing those that will motivate larger numbers of scientists to do their research differently as a consequence. In principle it should be possible to find a phenotype for each of the tens of thousands of genetic elements in the human genome, but not all such results will be equally informative. However, if, say, 50 other labs will drop everything and instead use the results of your work, that paper is certainly suitable for this journal!

    Well, there you go. The editorial also addresses pedigree research, stating that new identifications of Mendelian disorders in single families will not be sent for review.

    I think this all is appropriate, it's just interesting that research has advanced to the point that finding a genetic cause for a disorder is no longer a sufficient reason for publication. If you look through the GWAS Catalog, you find study after study published in Nature Genetics. Those days are probably numbered.


    References

    1. Anonymous. 2011. Full spectrum genetics. Nature genetics 44:1.
  • Scandal: grant reviewers favor work that is "original," "feasible"

    Sat, 2009-03-07 21:06 -- John Hawks

    OK, so that doesn't sound like a scandal. Yet, that's one of the themes of this Inside Higher Ed article:

    Michèle Lamont decided to explore excellence by studying one of the primary mechanisms used by higher education to -- in theory -- reward excellence: scholarly peer review. Applying sociological and other disciplinary approaches to her study, Lamont won the right to observe peer review panels that are normally closed to all outsiders. And she was able to interview peer review panelists before and after their meetings, examine notes of reviewers before and after decision-making meetings, and gain access to information on the outcomes of these decisions.

    Well, that sounds like it could be interesting. And maybe it was -- she wrote a book describing her work. But get a load of some of the "problems" she found:

    On diversity, Lamont’s research finds that peer reviewers do factor it in (although the extent to which they do so varies by discipline). But peer reviewers are much more likely to care about diversity of research topic or institution than gender or race, she finds.

    And:

    "I think excellence means nothing,” she said, suggesting that panels be honest about the criteria they use. “I think you have to give the criteria. Typically it's originality, feasibility, and also the social and intellectual significance.”

    In other words, the quality of the proposed research takes a front seat. Good.

    Lamont did observe some insidious practices. Panelists often were less critical of applicants from more prestigious institutions. She confusingly calls this "institutional affirmative action," I would call it Ivy League bigotry. And here's what the article says about humanities reviewers:

    Many humanities professors, she writes, “rank what promises to be ‘fascinating’ above what may turn out to be ‘true.’ ” She quotes an English professor she observed explaining the value of a particular project: “My thing is, even if it doesn’t work, I think it will provoke really fascinating conversations. So I was really not interested in whether it’s true or not.”

    Yes...ah...well...OK, then. Seems to me they might get better results with a random number generator.

    On the whole, she stresses the point that reviewers are biased toward their own interests and background. I think that's part of the system that we have to accept: otherwise, we may as well have robots evaluate grant applications. I think people would be a lot less likely to serve on panels if they couldn't put in a voice favoring their own perspective on the field -- not direct conflicts of interest, but intellectual philosophy and grounding.

    I wonder if Lamont was able to see the influence of those who select the panelists. Most people know that the composition of the panel determines funding successes and failures, and the people who invite or choose panelists ultimately choose the direction of the funding. That's a more secretive process than the panel deliberations themselves.

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Neandertals

For years, I've worked on their bones. Now I'm working on their genes. Read more about the science studying these ancient people.

Denisova

From a finger bone of an ancient human came the record of a completely unexpected population. My lab is working on the science of the Denisova genome.

Acceleration

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Malapa

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